Gene expression of nm23 has been investigated in number of tumors, including breast cancer, colon cancer, malignant melanoma, and hepatocellular carcinoma, Its down-regulation has been shown to be associated with metastasis or disease progression
in
some of the tumors. To elucidate the role of nm23 in human gastric carcinoma, sections of formalin-fixed, paraffin-embaded tissue from 50 primary stomach cancer were stained immunohistochemically against the nm23 protein.
There was a significant down-regulation of the nm23 gene in gastric cancer with serosal invasion(T3 and T4 by TNM clssification), nodal metastasis and in poorly differentiated tubular caaricnoma. .
It was suggested that the down-regulation of nm23 gene might have a role in metastasis and invasion in gastric cancer.
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